CKDu

The relationship between hydronephrosis severity on ultrasound and kidney stone size

Introduction Kidney stones are a common urologic condition, with an increasing incidence and prevalence globally. Non-contrast computed tomography (CT) is frequently used in emergency departments to evaluate suspected kidney stones, given its high accuracy for detecting the presence, size and location of stones. However, ultrasound is advantageous due to lower cost, lack of ionizing radiation, […]

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Association between pesticide exposure and chronic kidney disease of uncertain etiology in agricultural worker populations: A systematic review and meta-analysis

This proposed systematic review would compile evidence on the relationship between pesticide exposure and CKDu risk specifically in agricultural worker groups through meta-analysis of observational studies. It can evaluate the strength of association and sources of heterogeneity across different geographical regions and help identify research gaps to drive priorities for future epidemiological research on environmental/occupational

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Socio-economic determinants of Chronic Kidney Diseases of uncertain aetiology (CKDu)

  Introduction: – Presents the background and context of CKDu in Sri Lanka and globally. Highlights that CKDu is increasing in Uva Province but socio-economic risk factors are unknown. – Concisely states the study objectives to identify socio-economic risk factors for CKDu in Uva Province using statistical models. Methods: – Appropriate cross-sectional study design with

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Kidney Stones: A Potential Indicator of Fracture Risk in Chronic Kidney Disease

Introduction This study investigates the association between kidney stones and the risk of osteoporotic fracture in patients with chronic kidney disease (CKD). The introduction provides background on how CKD patients have a higher risk of osteoporotic fracture compared to the general population, and how bone mineral density alone has limitations in predicting fracture risk. The

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Describing Natural History and Exploring Risk Factors for Kidney Function Decline in Persons With CKD of Uncertain Etiology in Sri Lanka.

Pasan Hewavitharana1,2,11, Stephen Schensul3 , Edison Lee4 , Maria Montez-Rath4 , Sachintha Senarathne5 , Sai Liu4 , Kaitlin Harold4 , Santhushya Hewapathiranage1 , Naduni Erandika1 , Hemalika T.K. Abeysundara6 , Xue Yu4 , Vivek Bhalla4 , Andrew Fire7 , Adeera Levin8 , Shuchi Anand4 , Penny Vlahos9,11, Rohana Chandrajith5,11 and Nishantha Nanayakkara1,10,11 1 Center for

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Describing Natural History and Exploring Risk Factors for Kidney Function Decline in Persons With CKD of Uncertain Etiology in Sri Lanka. Read More »

Urinary MicroRNA Analysis Indicates an Epigenetic Regulation of Chronic Kidney Disease of Unknown Etiology in Sri Lanka.

Urinary MicroRNA Analysis Indicates an Epigenetic Regulation of Chronic Kidney Disease of Unknown Etiology in Sri Lanka. Thanuri Edirithilake 1, Nishantha Nanayakkara 2, Xiao Xiao Lin 3, Patrick J Biggs 4 5, Rohana Chandrajith 6, Sampath Lokugalappatti 1, Saumya Wickramasinghe 1 7 1 Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine and Animal Science,

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Leptospirosis: A Potential Culprit for Chronic Kidney Disease of Uncertain Etiology

Leptospirosis: A Potential Culprit for Chronic Kidney Disease of Uncertain Etiology Premarathne S.S.a,b · Gamage C.b · Chandrajith R.c · Ratnatunge N.V.d · Wijetunge S.d · Wazil A.e · Chou L.-F.f · Ko Y.-C.f · Huang C.-T.f · Yang H.-Y.f,g,h · Fonseka A.b · Sonnadara T.a · Herath D.a · Hewavitharane P.a · Yang C.-W.f,g,h

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Challenges and opportunities in interventions for chronic kidney disease of unknown origin (CKDu): report from the International Society of Nephrology Consortium of Collaborators on CKDu

Challenges and opportunities in interventions for chronic kidney disease of unknown origin (CKDu): report from the International Society of Nephrology Consortium of Collaborators on CKDu Brendan Smyth1,2 , Jason Glaser3 , Jaime Butler-Dawson4,5 , Nishantha Nanayakkara6 , David H. Wegman3,7 , Shuchi Anand8 and Adeera Levin9 1 National Health and Medical Research Council (NHMRC) Clinical

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Early ultrastructural changes in biopsies from patients with symptomatic CKDu (Sym-CKDu)

Christoph Daniel, Prof.1 ; Philipp Enghard, PD2 ; Neelakanthi Ratnatunga, Prof.3  ; Sulochana Wijetunge, Prof. 3 ; Wazil AWM, MD7 ; Christian Zwiener, Prof. 4 ; Johannes A.C. Barth, Prof.5 ; Rohana Chandrajith, Prof.6 ; Monika Klewer1 ; Kai-Uwe Eckhardt, Prof.2 , Kerstin Amann, Prof.1 ; Paul Freund, MD2 , Shakila Premarathne8 , W.D.R.N. Pushpakumara,

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