CKDu

Geoenvironmental Determinants Influencing Chronic Kidney Disease of Unknown Etiology in the dry zone of Sri Lanka: a study based on a cohort of at-risk communities

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Dhananjalee Mahalekam, Ishara Athauda, Penny Vlahos, Shuchi Anand, Nishantha Nanayakkara, Rohana Chandrajith   Abstract Chronic kidney disease of unknown origin (CKDu) has emerged as a serious health risk for farming communities in remote semi-arid lowland regions of Sri Lanka, with geoenvironmental factors widely believed to be associated with the etiology. Although numerous case–control studies have […]

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Spatial Analysis of Chronic Kidney Disease of Unknown Aetiology (CKDu) Prevalence in Badulupura Village, Sri Lanka

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B. S. Marasinghe, W. A. U. Vitharana, R. Chandrajith, N. Nanayakkara, H. P. U. Fonseka   Abstract This study investigated spatial patterns of chronic kidney disease of unknown aetiology (CKDu) patients in Badulupura village. The analysis utilized published locational data for all households, including households affected by CKDu, and all wells used by CKDu-affected patients

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 Sonographically determined kidney measurements are better able to predict histological changes and a low CKD-EPI eGFR when weighted towards cortical echogenicity

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 Introduction: – Renal ultrasound is commonly used to assess chronic kidney disease (CKD) patients. Some sonographic parameters like kidney length, cortical echogenicity, and cortical thickness correlate with renal function. – However, the accuracy of these crude parameters is limited. Weighting them towards cortical echogenicity may improve their ability to detect renal dysfunction and histological changes.

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 Sonographically determined kidney measurements are better able to predict histological changes and a low CKD-EPI eGFR when weighted towards cortical echogenicity Read More »

“Detailed Review of Chronic Kidney Disease”

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Abstract: This review examines a comprehensive overview of chronic kidney disease (CKD) published by Kakitapalli et al. in 2020. The original article covers the epidemiology, risk factors, diagnosis, management, and prevention of CKD. This review analyzes the key findings and contributions of the article to the current understanding of CKD. Introduction: Chronic kidney disease is

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The relationship between hydronephrosis severity on ultrasound and kidney stone size

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Introduction Kidney stones are a common urologic condition, with an increasing incidence and prevalence globally. Non-contrast computed tomography (CT) is frequently used in emergency departments to evaluate suspected kidney stones, given its high accuracy for detecting the presence, size and location of stones. However, ultrasound is advantageous due to lower cost, lack of ionizing radiation,

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Association between pesticide exposure and chronic kidney disease of uncertain etiology in agricultural worker populations: A systematic review and meta-analysis

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This proposed systematic review would compile evidence on the relationship between pesticide exposure and CKDu risk specifically in agricultural worker groups through meta-analysis of observational studies. It can evaluate the strength of association and sources of heterogeneity across different geographical regions and help identify research gaps to drive priorities for future epidemiological research on environmental/occupational

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Socio-economic determinants of Chronic Kidney Diseases of uncertain aetiology (CKDu)

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  Introduction: – Presents the background and context of CKDu in Sri Lanka and globally. Highlights that CKDu is increasing in Uva Province but socio-economic risk factors are unknown. – Concisely states the study objectives to identify socio-economic risk factors for CKDu in Uva Province using statistical models. Methods: – Appropriate cross-sectional study design with

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Kidney Stones: A Potential Indicator of Fracture Risk in Chronic Kidney Disease

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Introduction This study investigates the association between kidney stones and the risk of osteoporotic fracture in patients with chronic kidney disease (CKD). The introduction provides background on how CKD patients have a higher risk of osteoporotic fracture compared to the general population, and how bone mineral density alone has limitations in predicting fracture risk. The

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Describing Natural History and Exploring Risk Factors for Kidney Function Decline in Persons With CKD of Uncertain Etiology in Sri Lanka.

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Pasan Hewavitharana1,2,11, Stephen Schensul3 , Edison Lee4 , Maria Montez-Rath4 , Sachintha Senarathne5 , Sai Liu4 , Kaitlin Harold4 , Santhushya Hewapathiranage1 , Naduni Erandika1 , Hemalika T.K. Abeysundara6 , Xue Yu4 , Vivek Bhalla4 , Andrew Fire7 , Adeera Levin8 , Shuchi Anand4 , Penny Vlahos9,11, Rohana Chandrajith5,11 and Nishantha Nanayakkara1,10,11 1 Center for

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Describing Natural History and Exploring Risk Factors for Kidney Function Decline in Persons With CKD of Uncertain Etiology in Sri Lanka. Read More »

Urinary MicroRNA Analysis Indicates an Epigenetic Regulation of Chronic Kidney Disease of Unknown Etiology in Sri Lanka.

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Urinary MicroRNA Analysis Indicates an Epigenetic Regulation of Chronic Kidney Disease of Unknown Etiology in Sri Lanka. Thanuri Edirithilake 1, Nishantha Nanayakkara 2, Xiao Xiao Lin 3, Patrick J Biggs 4 5, Rohana Chandrajith 6, Sampath Lokugalappatti 1, Saumya Wickramasinghe 1 7 1 Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine and Animal Science,

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Urinary MicroRNA Analysis Indicates an Epigenetic Regulation of Chronic Kidney Disease of Unknown Etiology in Sri Lanka. Read More »

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