Research Publications

Prospective Biopsy-Based Study of CKD of Unknown Etiology in Sri Lanka

Shuchi Anand,1 Maria E. Montez-Rath,1 Dinuka Adasooriya,2,3 Neelakanthi Ratnatunga,4 Neeraja Kambham,5 Abdool Wazil,2 Sulcohana Wijetunge,4 Zeid Badurdeen,3 Charaka Ratnayake,2 Nishamani Karunasena,2 Stephen L. Schensul,6 Penny Valhos,7 Lalarukh Haider,8 Vivek Bhalla,1 Adeera Levin,9 Paul H. Wise,10 Glenn M. Chertow,1 Michele Barry,11 Andrew Z. Fire,5 and Nishantha Nanayakkara2,3   1 Division of Nephrology and Departments of 5 […]

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Screening for chronic kidney disease of uncertain aetiology in Sri Lanka: usability of surrogate biomarkers over dipstick proteinuria

Samantha Ratnayake1,2*, Zeid Badurdeen1 , Nishantha Nanayakkara3 , Tilak Abeysekara1 , Neelakanthi Ratnatunga4 and Ranjith Kumarasiri5   Abstract Background: The use of dipstick proteinuria to screen Chronic Kidney Disease of uncertain aetiology (CKDu) in Sri Lanka is a recently debated matter of dispute. The aim of this study was to assess the suitability of biomarkers:

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Epidemiology, molecular, and genetic methodologies to evaluate causes of CKDu around the world: report of the Working Group from the ISN International Consortium of Collaborators on CKDu

Shuchi Anand1 , Ben Caplin2 , Marvin Gonzalez-Quiroz2,3 , Stephen L. Schensul4 , Vivek Bhalla1 , Xavier Parada5 , Nishantha Nanayakkara6 , Andrew Fire1 , Adeera Levin7 and David J. Friedman8 , on behalf of International Society of Nephrology’s International Consortium of Collaborators on Chronic Kidney Disease of Unknown Etiology (i3C)9   1 School of Medicine,

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Epidemiology, molecular, and genetic methodologies to evaluate causes of CKDu around the world: report of the Working Group from the ISN International Consortium of Collaborators on CKDu Read More »

Prevalence, risk factors and predicted risk of cardiac events in chronic kidney disease of uncertain aetiology in Sri Lanka: A tubular interstitial nephropathy

Thilini W. Hettiarachchi1 *, Buddhi N. T. W. Fernando2 , Thilini Sudeshika3 , Zeid Badurdeen1 , Shuchi Anand4 , Ajith Kularatne5 , Sulochana Wijetunge6 , Hemalika T. K. Abeysundara7 , Nishantha Nanayakkara8 1 Centre for Education, Research and Training on Kidney Diseases (CERTKiD), Faculty of Medicine, University of Peradeniya, Galaha, Sri Lanka. 2 Department of

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Chronic Kidney Disease of Uncertain Etiology in Sri Lanka is a Possible Sequel of Interstitial Nephritis!

Zeid Badurdeen1, Nishantha Nanayakkara1,4, Neelakanthi V.I. Ratnatunga1,2, Abdul W.M. Wazil4, Tilak D.J. Abeysekera1, Premil N. Rajakrishna4, Jalitha P. Thinnarachchi4, Ranjith Kumarasiri3, Dulani D. Welagedera4, Needika Rajapaksha4, and Adambarage P.D. Alwis4 1Centre for Education Research and Training on Kidney Diseases (CERTKiD), < 2Department of Pathology, 3Department of Community Medicine, Faculty of Medicine, University of Peradeniya, Peradenya.

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Expanding CAPD In Low-Resource Settings: A Distance Learning Approach

Robert Rope1,* , Nishantha Nanayakkara2,* , Abdul Wazil2, Sewmini Dickowita2, Rajitha Abeyeskera2, Lishanthe Gunerathne3, Dinuka Adoosoriya2, Nishamani Karunasena2, Chrarake Rathnayake2, Shuchi Anand1, and Anjali Saxena1,4 1Division of Nephrology, Stanford University School of Medicine, Palo Alto, CA USA 2Teaching Hospital, Kandy, Sri Lanka; Renal Care & Research Unit 3Girandurukotte, Sri Lanka 4Division of Nephrology, Santa Clara

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Overcoming barriers and building a strong peritoneal dialysis programme – Experience from three South Asian countries.

Klara Paudel1, Ahad Qayyum2, Abdul WM Wazil3, Sanjib K Sharma4, Kalpana Shrestha5, Stanley Fan6, Agnes Haris7, Fredric O Finkelstein8, Nishanthe Nanayakkara3 1Department of Medicine, Charak Memorial Hospital, Pokhara, Nepal 2Department of Nephrology, Bahria Town Hospital, Lahore, Pakistan 3Department of Nephrology, Teaching Hospital, Kandy, Sri Lanka 4Department of Internal Medicine, BP Koirala Institute of Health Sciences,

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POS-224 IMPORTANCE OF SERUM ALDOSTERONE ON CHRONIC KIDNEY DISEASE OF UNCERTAIN AETIOLOGY IN SRI LANKA.

B. FERNANDO , N. Hewa Gajamanage , N. Nanayakkara Introduction The Chronic Kidney Disease of uncertain aetiology (CKDu), a recently described tubular interstitial nephropathy, is prevalent in tropical or subtropical countries including pockets in the farming dry zone of Sri Lanka, India, Nicaragua, Costa Rica, Egypt, and Tunisia. There is growing evidence to suggest that

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POS-224 IMPORTANCE OF SERUM ALDOSTERONE ON CHRONIC KIDNEY DISEASE OF UNCERTAIN AETIOLOGY IN SRI LANKA. Read More »

Prevalence, risk factors and predicted risk of cardiac events in chronic kidney disease of uncertain aetiology in Sri Lanka: A tubular interstitial nephropathy

Thilini W. Hettiarachchi , Buddhi N. T. W. Fernando, Thilini Sudeshika , Zeid Badurdeen , Shuchi Anand , Ajith Kularatne , Sulochana Wijetunge , Hemalika T. K. Abeysundara , Nishantha Nanayakkara   Abstract Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in patients with ‘traditional’ chronic kidney disease (CKD). However, chronic kidney

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Prevalence, risk factors and predicted risk of cardiac events in chronic kidney disease of uncertain aetiology in Sri Lanka: A tubular interstitial nephropathy Read More »

P.R4810K, a polymorphism of RNF213, the susceptibility gene for moyamoya disease, is associated with blood pressure

P.R4810K, a polymorphism of RNF213, the susceptibility gene for moyamoya disease, is associated with blood pressure

Akio Koizumi, Hatasu Kobayashi, Wanyang Liu, Yukiko Fujii, S. T. M. L. D. Senevirathna, Shanika Nanayakkara, Hiroko Okuda, Toshiaki Hitomi, Kouji H. Harada, Katsunobu Takenaka, Takao Watanabe, and Shinichiro Shimbo Abstract Background Moyamoya disease—an idiopathic vascular disorder of intracranial arteries—is often accompanied by hypertension. RNF213 has been identified as a susceptibility gene for moyamoya disease. In the present study, the association of p.R4810K (G[A) with blood pressure

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P.R4810K, a polymorphism of RNF213, the susceptibility gene for moyamoya disease, is associated with blood pressure Read More »

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