Abstracts

Geoenvironmental Determinants Influencing Chronic Kidney Disease of Unknown Etiology in the dry zone of Sri Lanka: a study based on a cohort of at-risk communities

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Dhananjalee Mahalekam, Ishara Athauda, Penny Vlahos, Shuchi Anand, Nishantha Nanayakkara, Rohana Chandrajith   Abstract Chronic kidney disease of unknown origin (CKDu) has emerged as a serious health risk for farming communities in remote semi-arid lowland regions of Sri Lanka, with geoenvironmental factors widely believed to be associated with the etiology. Although numerous case–control studies have […]

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Spatial Analysis of Chronic Kidney Disease of Unknown Aetiology (CKDu) Prevalence in Badulupura Village, Sri Lanka

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B. S. Marasinghe, W. A. U. Vitharana, R. Chandrajith, N. Nanayakkara, H. P. U. Fonseka   Abstract This study investigated spatial patterns of chronic kidney disease of unknown aetiology (CKDu) patients in Badulupura village. The analysis utilized published locational data for all households, including households affected by CKDu, and all wells used by CKDu-affected patients

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Tubulointerstitial nephropathy is the predominant finding in men in a review of more than 3000 renal biopsies over a 10-year period from Sri Lanka.

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Jennifer Pett1,2, Christine Linhart1*, Nicholas Osborne1,3*, Stephen Morrell1, Mohammed Fahim4,5, John Knight1,2, Shakila Premaranthne6,7, A. W. M. Wazil8, Neelakanthi Ratnatunga9, Sulcochana Wijethunga9, Shenal Thalgahagoda10, Zoltan Endre5,11, Richard Taylor1 and Nishantha Nanayakkara8   1 School of Population Health, University of New South Wales, UNSW, Sydney, Australia. 2 The George Institute for Global Health, Sydney, Australia. 3

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Tubulointerstitial nephropathy is the predominant finding in men in a review of more than 3000 renal biopsies over a 10-year period from Sri Lanka. Read More »

Screening of Micro-organic Compounds in Groundwater from Areas with Chronic Kidney Disease of Unclear Aetiology (CKDu) in the Dry Zone of Sri Lanka

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Rohana Chandrajith1, Christian Zwiener2, Christoph Daniel3, Kerstin Amann3, Nishantha Nanayakkara4, Johannes A. C. Barth5 1 Department of Geology, Faculty of Science, University of Peradeniya, Peradeniya, Sri Lanka. 2 Environmental Analytical Chemistry, Department of Geosciences, Eberhard-Karls-University Tübingen, Schnarrenbergstr. 94-96, 72076 Tübingen, Germany. 3 Institute of Pathologe, Department of Nephropathology, Friedrich-Alexander-Universität (FAU), Erlangen Nürnberg Krankenhausstr. 8-10, 91054

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Screening of Micro-organic Compounds in Groundwater from Areas with Chronic Kidney Disease of Unclear Aetiology (CKDu) in the Dry Zone of Sri Lanka Read More »

Socio-economic determinants of Chronic Kidney Diseases of uncertain aetiology (CKDu)

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  Introduction: – Presents the background and context of CKDu in Sri Lanka and globally. Highlights that CKDu is increasing in Uva Province but socio-economic risk factors are unknown. – Concisely states the study objectives to identify socio-economic risk factors for CKDu in Uva Province using statistical models. Methods: – Appropriate cross-sectional study design with

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Describing Natural History and Exploring Risk Factors for Kidney Function Decline in Persons With CKD of Uncertain Etiology in Sri Lanka.

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Pasan Hewavitharana1,2,11, Stephen Schensul3 , Edison Lee4 , Maria Montez-Rath4 , Sachintha Senarathne5 , Sai Liu4 , Kaitlin Harold4 , Santhushya Hewapathiranage1 , Naduni Erandika1 , Hemalika T.K. Abeysundara6 , Xue Yu4 , Vivek Bhalla4 , Andrew Fire7 , Adeera Levin8 , Shuchi Anand4 , Penny Vlahos9,11, Rohana Chandrajith5,11 and Nishantha Nanayakkara1,10,11 1 Center for

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Describing Natural History and Exploring Risk Factors for Kidney Function Decline in Persons With CKD of Uncertain Etiology in Sri Lanka. Read More »

The pattern of cytomegalovirus replication in post-renal transplant recipients with pre-emptive therapy strategy during the 1st year of post-transplantation.

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The pattern of cytomegalovirus replication in post-renal transplant recipients with pre-emptive therapy strategy during the 1st year of post-transplantation. Kalpa Dheerasekara 1, Rekshi Tharanga 1, Lakmali Rajamanthri 2, Abdul Wazil 3, Nishantha Nanayakkara 3, Rohitha Muthugala 2 1Department of Medical Laboratory Science, Faculty of Allied Health Sciences, University of Peradeniya, Sri Lanka. 2Department of Virology,

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The pattern of cytomegalovirus replication in post-renal transplant recipients with pre-emptive therapy strategy during the 1st year of post-transplantation. Read More »

Urinary MicroRNA Analysis Indicates an Epigenetic Regulation of Chronic Kidney Disease of Unknown Etiology in Sri Lanka.

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Urinary MicroRNA Analysis Indicates an Epigenetic Regulation of Chronic Kidney Disease of Unknown Etiology in Sri Lanka. Thanuri Edirithilake 1, Nishantha Nanayakkara 2, Xiao Xiao Lin 3, Patrick J Biggs 4 5, Rohana Chandrajith 6, Sampath Lokugalappatti 1, Saumya Wickramasinghe 1 7 1 Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine and Animal Science,

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Urinary MicroRNA Analysis Indicates an Epigenetic Regulation of Chronic Kidney Disease of Unknown Etiology in Sri Lanka. Read More »

Leptospirosis: A Potential Culprit for Chronic Kidney Disease of Uncertain Etiology

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Leptospirosis: A Potential Culprit for Chronic Kidney Disease of Uncertain Etiology Premarathne S.S.a,b · Gamage C.b · Chandrajith R.c · Ratnatunge N.V.d · Wijetunge S.d · Wazil A.e · Chou L.-F.f · Ko Y.-C.f · Huang C.-T.f · Yang H.-Y.f,g,h · Fonseka A.b · Sonnadara T.a · Herath D.a · Hewavitharane P.a · Yang C.-W.f,g,h

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Hantavirus infection as a risk factor for chronic kidney disease of unknown aetiology (CKDu) and its prevalence in endemic areas of Sri Lanka since 2010 according to a retrospective serological analysis

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Hantavirus infection as a risk factor for chronic kidney disease of unknown aetiology (CKDu) and its prevalence in endemic areas of Sri Lanka since 2010 according to a retrospective serological analysis Chandika D. Gamage1​, Shanika Nanayakkara2​,3​, Yomani D. Sarathkumara1​,4​, Devinda S. Muthusinghe5​,6​, Kenta Shimizu7​, Jiro Arikawa7​, Sithumini M. W. Lokupathirage5​,6​, Nishantha Nanayakkara8​, Lishanthe Gunarathne9​, Rohana

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Hantavirus infection as a risk factor for chronic kidney disease of unknown aetiology (CKDu) and its prevalence in endemic areas of Sri Lanka since 2010 according to a retrospective serological analysis Read More »

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