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Geoenvironmental Determinants Influencing Chronic Kidney Disease of Unknown Etiology in the dry zone of Sri Lanka: a study based on a cohort of at-risk communities

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Dhananjalee Mahalekam, Ishara Athauda, Penny Vlahos, Shuchi Anand, Nishantha Nanayakkara, Rohana Chandrajith   Abstract Chronic kidney disease of unknown origin (CKDu) has emerged as a serious health risk for farming communities in remote semi-arid lowland regions of Sri Lanka, with geoenvironmental factors widely believed to be associated with the etiology. Although numerous case–control studies have […]

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Geoenvironmental Determinants Influencing Chronic Kidney Disease of Unknown Etiology in the dry zone of Sri Lanka: a study based on a cohort of at-risk communities Read More »

Spatial Analysis of Chronic Kidney Disease of Unknown Aetiology (CKDu) Prevalence in Badulupura Village, Sri Lanka

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B. S. Marasinghe, W. A. U. Vitharana, R. Chandrajith, N. Nanayakkara, H. P. U. Fonseka   Abstract This study investigated spatial patterns of chronic kidney disease of unknown aetiology (CKDu) patients in Badulupura village. The analysis utilized published locational data for all households, including households affected by CKDu, and all wells used by CKDu-affected patients

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Spatial Analysis of Chronic Kidney Disease of Unknown Aetiology (CKDu) Prevalence in Badulupura Village, Sri Lanka Read More »

Tubulointerstitial nephropathy is the predominant finding in men in a review of more than 3000 renal biopsies over a 10-year period from Sri Lanka.

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Jennifer Pett1,2, Christine Linhart1*, Nicholas Osborne1,3*, Stephen Morrell1, Mohammed Fahim4,5, John Knight1,2, Shakila Premaranthne6,7, A. W. M. Wazil8, Neelakanthi Ratnatunga9, Sulcochana Wijethunga9, Shenal Thalgahagoda10, Zoltan Endre5,11, Richard Taylor1 and Nishantha Nanayakkara8   1 School of Population Health, University of New South Wales, UNSW, Sydney, Australia. 2 The George Institute for Global Health, Sydney, Australia. 3

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Tubulointerstitial nephropathy is the predominant finding in men in a review of more than 3000 renal biopsies over a 10-year period from Sri Lanka. Read More »

Screening of Micro-organic Compounds in Groundwater from Areas with Chronic Kidney Disease of Unclear Aetiology (CKDu) in the Dry Zone of Sri Lanka

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Rohana Chandrajith1, Christian Zwiener2, Christoph Daniel3, Kerstin Amann3, Nishantha Nanayakkara4, Johannes A. C. Barth5 1 Department of Geology, Faculty of Science, University of Peradeniya, Peradeniya, Sri Lanka. 2 Environmental Analytical Chemistry, Department of Geosciences, Eberhard-Karls-University Tübingen, Schnarrenbergstr. 94-96, 72076 Tübingen, Germany. 3 Institute of Pathologe, Department of Nephropathology, Friedrich-Alexander-Universität (FAU), Erlangen Nürnberg Krankenhausstr. 8-10, 91054

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Screening of Micro-organic Compounds in Groundwater from Areas with Chronic Kidney Disease of Unclear Aetiology (CKDu) in the Dry Zone of Sri Lanka Read More »

Review of “Hemodialysis leads to plasma depletion of lectin complement pathway initiator molecule ficolin-2” by Nielsen et al

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Study Overview This study by Nielsen et al. investigates the impact of hemodialysis (HD) on the complement system, specifically focusing on the lectin pathway initiator molecules ficolins. The main strengths of the study include its large sample size of 304 HD patients and the comprehensive assessment of various complement components and functional capacities. Key Findings

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 Sonographically determined kidney measurements are better able to predict histological changes and a low CKD-EPI eGFR when weighted towards cortical echogenicity

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 Introduction: – Renal ultrasound is commonly used to assess chronic kidney disease (CKD) patients. Some sonographic parameters like kidney length, cortical echogenicity, and cortical thickness correlate with renal function. – However, the accuracy of these crude parameters is limited. Weighting them towards cortical echogenicity may improve their ability to detect renal dysfunction and histological changes.

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 Sonographically determined kidney measurements are better able to predict histological changes and a low CKD-EPI eGFR when weighted towards cortical echogenicity Read More »

Critical review of the paper titled “Coronary Heart Disease Risks Associated with High Levels of HDL Cholesterol”

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Wilkins, J. T., Ning, H., Stone, N. J., Criqui, M. H., Zhao, L., Greenland, P., & Lloyd-Jones, D. M. (2014). Coronary heart disease risks associated with high levels of HDL cholesterol. Journal of the American Heart Association. Introduction The study by Wilkins et al. aimed to examine the association between very high levels of high-density

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Critical review of the paper titled “Coronary Heart Disease Risks Associated with High Levels of HDL Cholesterol” Read More »

Polyfluoroalkyl Substances in Food Packaging: Migration, Toxicity, and Management Strategies

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Research scope The article provides a comprehensive review of the presence of Per- and Polyfluoroalkyl Substances (PFASs) in food packaging. This is a significant contribution to the field as it brings together scattered information about PFASs in food packaging into one place. The authors have done an excellent job of collating and presenting this information

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Critical review of the article “A triple increase in global river basins with water scarcity due to future pollution”

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The study presents a comprehensive global assessment of future clean-water scarcity by incorporating the aspect of water pollution, specifically nitrogen pollution, into traditional assessments that focus solely on water quantity. The research integrates land-system, hydrological, and water quality models to analyze over 10,000 sub-basins, concluding that water pollution significantly exacerbates water scarcity in more than

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Critical review of the paper titled “The Impact of Obesity on Risk Factors and Prevalence and Prognosis of Coronary Heart Disease-The Obesity Paradox”

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De Schutter, A., Lavie, C. J., & Milani, R. V. (2014). The impact of obesity on risk factors and prevalence and prognosis of coronary heart disease—The obesity paradox. Progress in Cardiovascular Diseases, 56(4), 401-408. Introduction The paper by De Schutter et al. examines the relationship between obesity and coronary heart disease (CHD), with a particular

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Critical review of the paper titled “The Impact of Obesity on Risk Factors and Prevalence and Prognosis of Coronary Heart Disease-The Obesity Paradox” Read More »

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