Research Publications

Geoenvironmental Determinants Influencing Chronic Kidney Disease of Unknown Etiology in the dry zone of Sri Lanka: a study based on a cohort of at-risk communities

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Dhananjalee Mahalekam, Ishara Athauda, Penny Vlahos, Shuchi Anand, Nishantha Nanayakkara, Rohana Chandrajith   Abstract Chronic kidney disease of unknown origin (CKDu) has emerged as a serious health risk for farming communities in remote semi-arid lowland regions of Sri Lanka, with geoenvironmental factors widely believed to be associated with the etiology. Although numerous case–control studies have […]

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Spatial Analysis of Chronic Kidney Disease of Unknown Aetiology (CKDu) Prevalence in Badulupura Village, Sri Lanka

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B. S. Marasinghe, W. A. U. Vitharana, R. Chandrajith, N. Nanayakkara, H. P. U. Fonseka   Abstract This study investigated spatial patterns of chronic kidney disease of unknown aetiology (CKDu) patients in Badulupura village. The analysis utilized published locational data for all households, including households affected by CKDu, and all wells used by CKDu-affected patients

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Spatial Analysis of Chronic Kidney Disease of Unknown Aetiology (CKDu) Prevalence in Badulupura Village, Sri Lanka Read More »

Tubulointerstitial nephropathy is the predominant finding in men in a review of more than 3000 renal biopsies over a 10-year period from Sri Lanka.

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Jennifer Pett1,2, Christine Linhart1*, Nicholas Osborne1,3*, Stephen Morrell1, Mohammed Fahim4,5, John Knight1,2, Shakila Premaranthne6,7, A. W. M. Wazil8, Neelakanthi Ratnatunga9, Sulcochana Wijethunga9, Shenal Thalgahagoda10, Zoltan Endre5,11, Richard Taylor1 and Nishantha Nanayakkara8   1 School of Population Health, University of New South Wales, UNSW, Sydney, Australia. 2 The George Institute for Global Health, Sydney, Australia. 3

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Tubulointerstitial nephropathy is the predominant finding in men in a review of more than 3000 renal biopsies over a 10-year period from Sri Lanka. Read More »

Screening of Micro-organic Compounds in Groundwater from Areas with Chronic Kidney Disease of Unclear Aetiology (CKDu) in the Dry Zone of Sri Lanka

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Rohana Chandrajith1, Christian Zwiener2, Christoph Daniel3, Kerstin Amann3, Nishantha Nanayakkara4, Johannes A. C. Barth5 1 Department of Geology, Faculty of Science, University of Peradeniya, Peradeniya, Sri Lanka. 2 Environmental Analytical Chemistry, Department of Geosciences, Eberhard-Karls-University Tübingen, Schnarrenbergstr. 94-96, 72076 Tübingen, Germany. 3 Institute of Pathologe, Department of Nephropathology, Friedrich-Alexander-Universität (FAU), Erlangen Nürnberg Krankenhausstr. 8-10, 91054

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Screening of Micro-organic Compounds in Groundwater from Areas with Chronic Kidney Disease of Unclear Aetiology (CKDu) in the Dry Zone of Sri Lanka Read More »

Application effect of an artificial intelligence-based fundus screening system: evaluation in a clinical setting and population screening

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Introduction: – Ocular fundus abnormalities like diabetic retinopathy (DR), age-related macular degeneration (ARMD), retinal vein occlusion (RVO), and pathological myopia (PM) are major causes of blindness worldwide. – Early detection is crucial for preventing irreversible vision loss from these conditions. – AI systems based on fundus imaging like color fundus photography (CFP) have potential for

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The relationship between hydronephrosis severity on ultrasound and kidney stone size

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Introduction Kidney stones are a common urologic condition, with an increasing incidence and prevalence globally. Non-contrast computed tomography (CT) is frequently used in emergency departments to evaluate suspected kidney stones, given its high accuracy for detecting the presence, size and location of stones. However, ultrasound is advantageous due to lower cost, lack of ionizing radiation,

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Association between pesticide exposure and chronic kidney disease of uncertain etiology in agricultural worker populations: A systematic review and meta-analysis

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This proposed systematic review would compile evidence on the relationship between pesticide exposure and CKDu risk specifically in agricultural worker groups through meta-analysis of observational studies. It can evaluate the strength of association and sources of heterogeneity across different geographical regions and help identify research gaps to drive priorities for future epidemiological research on environmental/occupational

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Inside the bold mission to map every immune system in the world

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Introduction The article “Inside the bold mission to map every immune system in the world” by James Lloyd, published in BBC Science Focus Magazine in January 2024, discusses the aims and challenges of the Human Immunome Project (HIP), a global initiative that seeks to create a digital library of the immune system of every human

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Socio-economic determinants of Chronic Kidney Diseases of uncertain aetiology (CKDu)

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  Introduction: – Presents the background and context of CKDu in Sri Lanka and globally. Highlights that CKDu is increasing in Uva Province but socio-economic risk factors are unknown. – Concisely states the study objectives to identify socio-economic risk factors for CKDu in Uva Province using statistical models. Methods: – Appropriate cross-sectional study design with

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Describing Natural History and Exploring Risk Factors for Kidney Function Decline in Persons With CKD of Uncertain Etiology in Sri Lanka.

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Pasan Hewavitharana1,2,11, Stephen Schensul3 , Edison Lee4 , Maria Montez-Rath4 , Sachintha Senarathne5 , Sai Liu4 , Kaitlin Harold4 , Santhushya Hewapathiranage1 , Naduni Erandika1 , Hemalika T.K. Abeysundara6 , Xue Yu4 , Vivek Bhalla4 , Andrew Fire7 , Adeera Levin8 , Shuchi Anand4 , Penny Vlahos9,11, Rohana Chandrajith5,11 and Nishantha Nanayakkara1,10,11 1 Center for

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Describing Natural History and Exploring Risk Factors for Kidney Function Decline in Persons With CKD of Uncertain Etiology in Sri Lanka. Read More »

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