Research Publications

Network Meta-Analysis of Atypical Antipsychotics in Bipolar Depression

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This Bayesian network meta-analysis, published in BMC Psychiatry (2021), addresses a clinically significant gap by comparing atypical antipsychotics for bipolar depression through indirect evidence synthesis. The study’s methodology is appropriately sophisticated, employing network meta-analysis to overcome the absence of direct head-to-head trials between these medications. Strengths: The research design effectively leverages available randomised controlled trial […]

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Critical Review of Integrated Dengue Prevention: Environmental Cleanliness and Community Awareness

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This review critically evaluates current dengue prevention strategies, with a focused lens on the interrelated roles of environmental cleanliness and community awareness. Dengue, transmitted predominantly by Aedes aegypti, remains a significant global health threat. exacerbated by urbanization, climate change, and globalization. With no widely effective antiviral treatment and only limited vaccine success, preventive measures remain

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“The COVID-19 pandemic: consequences for nephrology”

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Source – https://doi.org/10.3390/biomedicines11030926 Introduction The article by Annette Bruchfeld, published in Nature Reviews Nephrology (February 2021) provides a timely analysis of COVID-19’s impact on nephrology. The article effectively summarises early research findings from 2020 regarding the relationship between COVID-19 and kidney disease. This review will evaluate the article’s scientific merits, methodological approach, findings, limitations, and

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Critical Review: Sri Lanka’s Mental Health Crisis – Underfunding, Stigma, and Service Gaps

Leave a Comment / Medical and Health Sciences /

Three main issues affect mental health in Sri Lanka: limited finances, much stigma, and poor services, particularly in rural areas.  Despite having effective policies, inequalities are still generated by inefficiencies and cultural factors.  Approximately 13.3% of people experience untreated mental illness as a result (Mental Health in Sri Lanka A Summary – Join Health, n.d.;

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Potential diagnostic biomarkers for chronic kidney disease of unknown etiology (CKDu) in Sri Lanka: a pilot study

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Critical Review Introduction The study by Sayanthooran et al. (2017) explores a significant public health issue in Sri Lanka—chronic kidney disease of unknown etiology (CKDu)—which predominantly affects farming communities in dry zones. Unlike typical CKD cases, which are often linked to diabetes or hypertension, CKDu lacks a clearly defined cause. The researchers aimed to identify

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Critical review of “Artificial Intelligence as a Replacement for Animal Experiments in Neurology: Potential, Progress, and Challenges” by Thorsten Rudroff

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  Thorsten Rudroff’s 2024 perspective article explores the transformative potential of artificial intelligence (AI) to supplant animal experimentation in neurology. The article offers a comprehensive and optimistic overview of emerging AI methodologies, including brain organoids, computational modeling, and machine learning, positing them as superior alternatives to traditional animal-based research. While the article is rich in

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Distinctive Patterns of Trace Elements in Chronic Kidney Disease of Uncertain Etiology: Comparative Analysis Across Multiple Control Groups

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Buddhi N. T. Fernando 1,2 ,Nishantha Nanayakkara 3 ,Rohana Chandrajith 4 ,Hemalika T. K. Abeysundara 5 and Dulanjali Herath 6 1 Centre for Education, Research and Training on Kidney Diseases, University of Peradeniya, Peradeniya 20400, Sri Lanka 2 Department of Medical Laboratory Science, Faculty of Allied Health Sciences, University of Ruhuna, Walahanduwa, Galle 80000, Sri

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Making the Case for New Donor Selection Criteria in CKDu Endemic Areas: A Crucial Step for Sustainable Kidney Transplantation in Sri Lanka.

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Naduni Erandika BSc,1 Rajitha Abeysekera MD,2 Sulochana Wijetunge MD,3 Hemalika Abeysundara PhD,4 Abdul Wazil MD,1 Neelakanthi Ratnatunga PhD,3 and Nishantha Nanayakkara MD1   CHRONIC KIDNEY DISEASE PREVALENCE IN SRI LANKA. Sri Lanka is an island nation of 21 million people with a high burden of chronic kidney disease (CKD) due to diabetes and hypertension.1 CKD

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Meet an Expert – Session 1

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We were honored to host Professor Jayantha Gunaratne, Senior Principal Investigator at IMCB A*STAR Singapore and Associate Professor at NUS School of Medicine, for an exceptional ‘Meet an Expert’ session. Professor Gunaratne shared groundbreaking insights on proteomics and its biomedical applications, fostering valuable discussions with our medical professionals. Special thanks to our Director and all

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Geoenvironmental Determinants Influencing Chronic Kidney Disease of Unknown Etiology in the dry zone of Sri Lanka: a study based on a cohort of at-risk communities

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Dhananjalee Mahalekam, Ishara Athauda, Penny Vlahos, Shuchi Anand, Nishantha Nanayakkara, Rohana Chandrajith   Abstract Chronic kidney disease of unknown origin (CKDu) has emerged as a serious health risk for farming communities in remote semi-arid lowland regions of Sri Lanka, with geoenvironmental factors widely believed to be associated with the etiology. Although numerous case–control studies have

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