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Research Review: Microplastic Pollution and Human Health Risk Assessment

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Introduction Microplastic pollution has emerged as one of the most pressing environmental challenges of our time, with far-reaching implications for ecosystem health and human well-being. This research review examines the current understanding of microplastic distribution, sources, exposure pathways, and potential health impacts based on recent scientific literature. Overview of Microplastic Contamination Definition and Sources Microplastics […]

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Etiological Factors of Gastrointestinal Cancer and the Association Between Diet Quality in Sri Lanka

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Gastrointestinal (GI) cancers—gastric, oesophageal, and colorectal cancers—are a severe and growing public health problem in Sri Lanka, driven by genetic predisposition as well as a complex interaction of lifestyle and environmental risk factors. Food quality is the strongest modifiable risk factor determining both disease occurrence and disease outcome among them. The following broader critical overview

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The Order of Draw and Rationale of Blood Collection Tubes: A Review of Guidelines and Pre-Analytical Considerations

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    Accurate blood collection is an important step in patient care because most diagnoses depend on lab tests (WHO, 2010). Errors made before analysis, the “pre-analytical phase”, cause up to 70% of laboratory mistakes (Njoroge and Nichols, 2014; Dagher et al., 2019). Tubes used in venipuncture contain additives that directly influence the blood sample

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Network Meta-Analysis of Atypical Antipsychotics in Bipolar Depression

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This Bayesian network meta-analysis, published in BMC Psychiatry (2021), addresses a clinically significant gap by comparing atypical antipsychotics for bipolar depression through indirect evidence synthesis. The study’s methodology is appropriately sophisticated, employing network meta-analysis to overcome the absence of direct head-to-head trials between these medications. Strengths: The research design effectively leverages available randomised controlled trial

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Critical Review of Integrated Dengue Prevention: Environmental Cleanliness and Community Awareness

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This review critically evaluates current dengue prevention strategies, with a focused lens on the interrelated roles of environmental cleanliness and community awareness. Dengue, transmitted predominantly by Aedes aegypti, remains a significant global health threat. exacerbated by urbanization, climate change, and globalization. With no widely effective antiviral treatment and only limited vaccine success, preventive measures remain

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“The COVID-19 pandemic: consequences for nephrology”

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Source – https://doi.org/10.3390/biomedicines11030926 Introduction The article by Annette Bruchfeld, published in Nature Reviews Nephrology (February 2021) provides a timely analysis of COVID-19’s impact on nephrology. The article effectively summarises early research findings from 2020 regarding the relationship between COVID-19 and kidney disease. This review will evaluate the article’s scientific merits, methodological approach, findings, limitations, and

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Critical review of the article on ‘Patient Management and Clinical Outcomes Associated with a Recorded Diagnosis of Stage 3 Chronic Kidney Disease: The REVEAL-CKD Study’

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Citation: Tangri, N., Peach, E. J., Franzén, S., Barone, S., & Kushner, P. R. (2023). Patient management and clinical outcomes associated with a recorded diagnosis of stage 3 chronic kidney disease: the REVEAL-CKD study. Advances in Therapy, 40(6), 2869-2885. Introduction Chronic kidney disease (CKD) is a major public health concern [1], and its prevalence is

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Critical Review: Sri Lanka’s Mental Health Crisis – Underfunding, Stigma, and Service Gaps

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Three main issues affect mental health in Sri Lanka: limited finances, much stigma, and poor services, particularly in rural areas.  Despite having effective policies, inequalities are still generated by inefficiencies and cultural factors.  Approximately 13.3% of people experience untreated mental illness as a result (Mental Health in Sri Lanka A Summary – Join Health, n.d.;

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Potential diagnostic biomarkers for chronic kidney disease of unknown etiology (CKDu) in Sri Lanka: a pilot study

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Critical Review Introduction The study by Sayanthooran et al. (2017) explores a significant public health issue in Sri Lanka—chronic kidney disease of unknown etiology (CKDu)—which predominantly affects farming communities in dry zones. Unlike typical CKD cases, which are often linked to diabetes or hypertension, CKDu lacks a clearly defined cause. The researchers aimed to identify

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Critical review of “Artificial Intelligence as a Replacement for Animal Experiments in Neurology: Potential, Progress, and Challenges” by Thorsten Rudroff

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  Thorsten Rudroff’s 2024 perspective article explores the transformative potential of artificial intelligence (AI) to supplant animal experimentation in neurology. The article offers a comprehensive and optimistic overview of emerging AI methodologies, including brain organoids, computational modeling, and machine learning, positing them as superior alternatives to traditional animal-based research. While the article is rich in

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