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Geoenvironmental Determinants Influencing Chronic Kidney Disease of Unknown Etiology in the dry zone of Sri Lanka: a study based on a cohort of at-risk communities

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Dhananjalee Mahalekam, Ishara Athauda, Penny Vlahos, Shuchi Anand, Nishantha Nanayakkara, Rohana Chandrajith   Abstract Chronic kidney disease of unknown origin (CKDu) has emerged as a serious health risk for farming communities in remote semi-arid lowland regions of Sri Lanka, with geoenvironmental factors widely believed to be associated with the etiology. Although numerous case–control studies have […]

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Spatial Analysis of Chronic Kidney Disease of Unknown Aetiology (CKDu) Prevalence in Badulupura Village, Sri Lanka

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B. S. Marasinghe, W. A. U. Vitharana, R. Chandrajith, N. Nanayakkara, H. P. U. Fonseka   Abstract This study investigated spatial patterns of chronic kidney disease of unknown aetiology (CKDu) patients in Badulupura village. The analysis utilized published locational data for all households, including households affected by CKDu, and all wells used by CKDu-affected patients

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Tubulointerstitial nephropathy is the predominant finding in men in a review of more than 3000 renal biopsies over a 10-year period from Sri Lanka.

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Jennifer Pett1,2, Christine Linhart1*, Nicholas Osborne1,3*, Stephen Morrell1, Mohammed Fahim4,5, John Knight1,2, Shakila Premaranthne6,7, A. W. M. Wazil8, Neelakanthi Ratnatunga9, Sulcochana Wijethunga9, Shenal Thalgahagoda10, Zoltan Endre5,11, Richard Taylor1 and Nishantha Nanayakkara8   1 School of Population Health, University of New South Wales, UNSW, Sydney, Australia. 2 The George Institute for Global Health, Sydney, Australia. 3

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Tubulointerstitial nephropathy is the predominant finding in men in a review of more than 3000 renal biopsies over a 10-year period from Sri Lanka. Read More »

Screening of Micro-organic Compounds in Groundwater from Areas with Chronic Kidney Disease of Unclear Aetiology (CKDu) in the Dry Zone of Sri Lanka

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Rohana Chandrajith1, Christian Zwiener2, Christoph Daniel3, Kerstin Amann3, Nishantha Nanayakkara4, Johannes A. C. Barth5 1 Department of Geology, Faculty of Science, University of Peradeniya, Peradeniya, Sri Lanka. 2 Environmental Analytical Chemistry, Department of Geosciences, Eberhard-Karls-University Tübingen, Schnarrenbergstr. 94-96, 72076 Tübingen, Germany. 3 Institute of Pathologe, Department of Nephropathology, Friedrich-Alexander-Universität (FAU), Erlangen Nürnberg Krankenhausstr. 8-10, 91054

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Review of “Human C-terminal CUBN variants associate with chronic proteinuria and normal renal function”

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Introduction and Background: The introduction provides a comprehensive overview of the significance of proteinuria, its causes, and the role of cubilin in protein reabsorption by the proximal tubules. It effectively summarizes the existing knowledge on the link between CUBN mutations and Imerslund-Gräsbeck syndrome (IGS) and proteinuria. Study Design and Methods The authors have utilized three

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Application effect of an artificial intelligence-based fundus screening system: evaluation in a clinical setting and population screening

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Introduction: – Ocular fundus abnormalities like diabetic retinopathy (DR), age-related macular degeneration (ARMD), retinal vein occlusion (RVO), and pathological myopia (PM) are major causes of blindness worldwide. – Early detection is crucial for preventing irreversible vision loss from these conditions. – AI systems based on fundus imaging like color fundus photography (CFP) have potential for

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“Detailed Review of Chronic Kidney Disease”

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Abstract: This review examines a comprehensive overview of chronic kidney disease (CKD) published by Kakitapalli et al. in 2020. The original article covers the epidemiology, risk factors, diagnosis, management, and prevention of CKD. This review analyzes the key findings and contributions of the article to the current understanding of CKD. Introduction: Chronic kidney disease is

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Critical review of the article on ‘Time-zero renal biopsy in living kidney transplantation: a valuable opportunity to correlate pre-donation clinical data with histological abnormalities’

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Citation: Mancilla, E., Avila-Casado, C., Uribe-Uribe, N., Morales-Buenrostro, L. E., Rodríguez, F., Vilatoba, M., … & Alberú, J. (2008). Time-zero renal biopsy in living kidney transplantation: a valuable opportunity to correlate predonation clinical data with histological abnormalities. Transplantation, 86(12), 1684-1688. Introduction In this study, they analyzed histologic characteristics of kidney biopsies obtained at the time

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Critical review of the article on ‘Time-zero renal biopsy in living kidney transplantation: a valuable opportunity to correlate pre-donation clinical data with histological abnormalities’ Read More »

Review of Urinary proteomics in chronic kidney disease: diagnosis and risk of progression beyond albuminuria

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Summary This study examined the utility of urinary proteomics analysis using capillary electrophoresis coupled to mass spectrometry (CE-MS) for diagnosing chronic kidney disease (CKD) and predicting rapid kidney function decline. The authors analyzed urine samples from 18 CKD patients (including those with hypertensive nephropathy) and 17 healthy controls. They found that a urinary proteomic classifier

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Association Between Occupational Heat Stress and Kidney Disease Among 37,816 Workers in the Thai Cohort Study (TCS)

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Introduction – Provides background on the rising issue of heat stress due to climate change and its potential health impacts, including kidney disease. – Highlights the lack of studies examining the association between occupational heat stress and kidney disease, particularly in tropical countries like Thailand. – Outlines the objectives of the study to examine this

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