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Lack of evidence for viral etiology in symptomatic chronic kidney disease of unknown etiology (CKDu) in Sri Lanka

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Lack of evidence for viral etiology in symptomatic chronic kidney disease of unknown etiology (CKDu) in Sri Lanka   Nilantha Pushpakumara1,2 , Paul Freund3,4, Shakila Premarathne1,2 , Pasan Hewavitharane1,2 , Naduni Erandika1,2 , Dulanjali Herath1,2 , Thilini Weerakoon1,2, Sulochana Wijethunga5 , Neelakanthi Ratnatunga5 , Abdul Wazil2 , Christopher M. Skopnik3,4, Diana Metzke3,4, Julia Melchert6,7, Tobias […]

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Research Review: Microplastic Pollution and Human Health Risk Assessment

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Introduction Microplastic pollution has emerged as one of the most pressing environmental challenges of our time, with far-reaching implications for ecosystem health and human well-being. This research review examines the current understanding of microplastic distribution, sources, exposure pathways, and potential health impacts based on recent scientific literature. Overview of Microplastic Contamination Definition and Sources Microplastics

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Etiological Factors of Gastrointestinal Cancer and the Association Between Diet Quality in Sri Lanka

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Gastrointestinal (GI) cancers—gastric, oesophageal, and colorectal cancers—are a severe and growing public health problem in Sri Lanka, driven by genetic predisposition as well as a complex interaction of lifestyle and environmental risk factors. Food quality is the strongest modifiable risk factor determining both disease occurrence and disease outcome among them. The following broader critical overview

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The Order of Draw and Rationale of Blood Collection Tubes: A Review of Guidelines and Pre-Analytical Considerations

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    Accurate blood collection is an important step in patient care because most diagnoses depend on lab tests (WHO, 2010). Errors made before analysis, the “pre-analytical phase”, cause up to 70% of laboratory mistakes (Njoroge and Nichols, 2014; Dagher et al., 2019). Tubes used in venipuncture contain additives that directly influence the blood sample

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Network Meta-Analysis of Atypical Antipsychotics in Bipolar Depression

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This Bayesian network meta-analysis, published in BMC Psychiatry (2021), addresses a clinically significant gap by comparing atypical antipsychotics for bipolar depression through indirect evidence synthesis. The study’s methodology is appropriately sophisticated, employing network meta-analysis to overcome the absence of direct head-to-head trials between these medications. Strengths: The research design effectively leverages available randomised controlled trial

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Critical Review of Integrated Dengue Prevention: Environmental Cleanliness and Community Awareness

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This review critically evaluates current dengue prevention strategies, with a focused lens on the interrelated roles of environmental cleanliness and community awareness. Dengue, transmitted predominantly by Aedes aegypti, remains a significant global health threat. exacerbated by urbanization, climate change, and globalization. With no widely effective antiviral treatment and only limited vaccine success, preventive measures remain

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“The COVID-19 pandemic: consequences for nephrology”

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Source – https://doi.org/10.3390/biomedicines11030926 Introduction The article by Annette Bruchfeld, published in Nature Reviews Nephrology (February 2021) provides a timely analysis of COVID-19’s impact on nephrology. The article effectively summarises early research findings from 2020 regarding the relationship between COVID-19 and kidney disease. This review will evaluate the article’s scientific merits, methodological approach, findings, limitations, and

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Critical review of the article on ‘Patient Management and Clinical Outcomes Associated with a Recorded Diagnosis of Stage 3 Chronic Kidney Disease: The REVEAL-CKD Study’

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Citation: Tangri, N., Peach, E. J., Franzén, S., Barone, S., & Kushner, P. R. (2023). Patient management and clinical outcomes associated with a recorded diagnosis of stage 3 chronic kidney disease: the REVEAL-CKD study. Advances in Therapy, 40(6), 2869-2885. Introduction Chronic kidney disease (CKD) is a major public health concern [1], and its prevalence is

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Critical Review: Sri Lanka’s Mental Health Crisis – Underfunding, Stigma, and Service Gaps

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Three main issues affect mental health in Sri Lanka: limited finances, much stigma, and poor services, particularly in rural areas.  Despite having effective policies, inequalities are still generated by inefficiencies and cultural factors.  Approximately 13.3% of people experience untreated mental illness as a result (Mental Health in Sri Lanka A Summary – Join Health, n.d.;

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