WARNAKULASURIYA BNT FERNANDO,1 THILINI W HETTIARACHCHI,1 THILINI SUDESHIKA,2 ZEID BADURDEEN,1
HEMALIKA ABEYSUNDARA,3 SHIRANI RANASINGHE,4 MANEL P RATHNAYAKE5 and NISHANTHA NANAYAKKARA6
1
Centre for Education, Research and Training on Kidney Diseases (CERTKiD), Faculty of Medicine, University of Peradeniya,
2Department of Pharmacy, Facultyof Allied Health Sciences, University of Peradeniya,
3Department of Statistics and Computer Science, Faculty of Science, University of Peradeniya,
4Department of Biochemistry, Faculty of Medicine, University of Peradeniya,
5Department of Pathology, Faculty of Medicine, University of Peradeniya,
6Transplant and Dialysis Unit, Teaching Hospital, Kandy, Sri Lanka
ABSTRACT:
Aim: Anaemia is a well-known complication of chronic kidney disease but
there are no published studies on the pattern of anaemia in chronic kidney disease of uncertain aetiology (CKDu). This study aims to find out the prevalence,
causes and associations of anaemia in CKDu to identify any unique features
which are different from already described anaemia in chronic kidney disease.
Method: All (119) biopsy-confirmed CKDu patients in two endemic clinics
(Girandurukotte and Wilgamuwa) were selected as cases. Blood samples
(10 mL) were collected from the peripheral veins into Potassium-Ethylenediaminetetraacetic acid (K-EDTA) tubes, plain tubes and Na-citrated tubes.
Serum was separated immediately by centrifugation at 3000 rpm for
10 min. Spot urine samples were collected into empty, sterile, polypropylene urine containers. All analyses were performed in IBM SPSS statistics version 23 (IBM Corp, Armonk, New York).
Results: The overall prevalence of anaemia in 119 non-dialysis CKDu
patients was 72.3% with the highest prevalence seen in females compared
to males (P < 0.001). The prevalence of anaemia in CKDu patients with progression to renal failure was 66.7% – stage 1, 60% – stage 2, 50% – stage 3a,
95% – stage 3b, 79.2% – stage 4 and 100% – stage 5 (P = 0.005). Of CKDu
patients, 44.3% had anaemia of chronic disease with iron deficiency. CKDu
patients with anaemia had a high inflammatory score were seen in both
early and late stages of CKDu. There were a similar proportion of patients
with both early and late CKDu having unexplained anaemia.
Conclusion: The current study showed a significant association of anaemia
with disease severity among CKDu patients. Iron deficiency is a crucial
aetiology factor of anaemia in CKDu and inflammation likely to effects
adversely on anaemia of CKDu.
More Details: https://pubmed.ncbi.nlm.nih.gov/30525261/
