B. S. Marasinghe, W. A. U. Vitharana, R. Chandrajith, N. Nanayakkara, H. P. U. Fonseka
Abstract
This study investigated spatial patterns of chronic kidney disease of unknown aetiology (CKDu) patients in Badulupura village. The analysis utilized published locational data for all households, including households affected by CKDu, and all wells used by CKDu-affected patients (CPA wells). The study employed Average Nearest Neighbour (ANN) and Hot Spot Analysis (Getis-Ord Gi*) tools to assess the spatial clustering of CKDu households and CPA wells. The study also explored the impact of topographical factors such as elevation, slope, and distance to watershed boundaries on the spatial distribution of CKDu patients. The ANN analysis revealed a dispersed pattern for all wells, and a random distribution for all households. However, both CKDu households and CPI wells exhibited a clustered pattern, suggesting a location-specific cause for the spatial distribution of the disease. Additionally, overlaying CKDu-affected households on the digital elevation model revealed a concentration of CKDu hot spots in high-elevation areas, while cold spots were observed in low-elevation regions. Furthermore, the t-test was employed to investigate the significance of elevation, slope, and distance to the watershed boundaries in relation to CKDu distribution. The results indicated a significant (p<0.05) prevalence of CKDu in high-elevation areas, while no significant association was found with slope or distance to watershed boundaries. The study revealed the presence of localized CKDu hot spots and cold spots within a small geographical area, highlighting the importance of considering topographical factors and conducting comprehensive hydrogeological and geological studies to gain valuable insights into the spatial distribution of CKDu.
Keywords: CKDu, Spatial distribution, Topography
